Yossi Vardi began his entrepreneurial career in 1969, at the age of 26, as co-founder and first CEO of TEKEM, one of the first software houses in Israel (later sold to Tadiran and then absorbed into Ness Technologies). In 1970, he was appointed Director General of the Ministry of Development. He served as chairman of Israel Chemicals of Mifaley Tovala, of Harsit and Hol Zach, and a member of the board of Israel Electric Corporation, Dead Sea Works, Dead Sea Bromine, Dead Sea Periclase, Haifa Chemicals, Chemicals and Phosphates, and others. He also chaired the Oil Explorations Concessions Council and Fertilizers Development Council.
He was sent to the U.S. to serve as the Director of the Investment Authority in North America, and Consul For Economic Affairs of the State of Israel in New York. In that capacity he took part in the creation of the Israel-U.S. Binational Industrial Research and Development Foundation (BIRD-F). He acted as an advisor to the Israeli mission to the U.N..
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